This is the complete keynote address delivered by Dr. Alfredo Sfeir-Younis, a distinguished speaker at the Humanity Transformation Conference 2025 (HTC 2025), hosted by The Middle Way Institute. Convened at the BMCC Tribeca Performing Arts Center, the conference gathered global thinkers to explore the application of ancient spiritual wisdom to modern personal and societal challenges. Dr. Sfeir-Younis’s presentation meticulously addresses the conference's central theme: "Wisdom and Compassion in a Fragmented World." This discourse provides substantive, specialized perspectives intended to guide practitioners in navigating the complexities of the contemporary global milieu.