Grab the tissues—this one hurts. Join us as we revisit the most heartbreaking farewells in Grey’s Anatomy history. Our countdown includes Derek Shepherd, George O’Malley, Lexie Grey, Mark Sloan, Denny Duquette, and more beloved characters whose exits shattered us. From the bomb squad tragedy to the plane crash and beyond, we’re reliving the toughest goodbyes. Which loss wrecked you the most? Share your pick in the comments! Spoilers ahead!
